FAIM Enhances the Efficacy of Mesenchymal Stem Cell Transplantation by Inhibiting JNK-Induced c-FLIP Ubiquitination and Degradation.

Jinyong ChenFeng LiuWangxing HuYi QianDilin XuChenyang GaoZhiru ZengSi ChengLan XieKaixiang YuGangjie ZhuXianbao Liu

Published in: Stem cells international (2022)

Overall, these results indicated that FAIM curbed the JNK-mediated, ubiquitination-proteasome-dependent degradation of c-FLIP, thereby improving the survival of transplanted MSCs and enhancing their efficacy in MI. This study may provide a novel approach to strengthen the therapeutic effect of MSC-based therapy.

Keyphrases

stem cell transplantation
signaling pathway
high dose
cell death
induced apoptosis
mesenchymal stem cells
high glucose
bone marrow
diabetic rats
drug induced
oxidative stress
free survival
endothelial cells
replacement therapy