Mortality associations with DNA methylation-based biological aging and physical functioning measures across a 20-year follow-up period.

Tiina Föhr Katja WallerAnne ViljanenTaina RantanenJaakko KaprioMiina OllikainenElina Sillanpää

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2023)

The findings suggest that DNAm GrimAge and the TUG test are strong predictors of mortality independent of each other's and genetic influences. DNAm-based measures and functional tests capture different aspects of the aging process and thus complement each other as measures of biological aging in predicting mortality.

Keyphrases

dna methylation
cardiovascular events
risk factors
genome wide
gene expression
physical activity
mental health
type diabetes
cardiovascular disease
copy number
nk cells