Change in medial frontal cerebral metabolite concentrations following bariatric surgery.
Sarah A BottariRonald CohenJeffrey FriedmanEric PorgesAlexa ChenMark BrittonJohn GunstadAdam WoodsJohn WilliamsonPublished in: NMR in biomedicine (2023)
Participants who underwent bariatric surgery exhibited reductions in cerebral Cho and mI concentrations, which were associated with improvements in weight loss and glycemic control. Given that elevated levels of Cho and mI have been implicated in neuroinflammation, reduction in these metabolites after bariatric surgery may reflect amelioration of obesity-related neuroinflammatory processes. As such, our results provide evidence that bariatric surgery may improve brain health and metabolism in individuals with obesity.
Keyphrases
- weight loss
- bariatric surgery
- glycemic control
- obese patients
- cerebral ischemia
- roux en y gastric bypass
- gastric bypass
- subarachnoid hemorrhage
- blood glucose
- type diabetes
- weight gain
- healthcare
- public health
- mental health
- functional connectivity
- resting state
- traumatic brain injury
- brain injury
- ms ms
- white matter
- insulin resistance
- health information
- metabolic syndrome
- blood brain barrier
- body mass index
- social media
- cognitive impairment
- lps induced
- health promotion
- climate change