Lysine demethylase 5C inhibits transcription of prefoldin subunit 5 to activate c-Myc signal transduction and colorectal cancer progression.
Fulong YuLiang LiYimei GuSong WangLianbang ZhouXiaohu ChengHeng JiangYang HuangYingfeng ZhangWenbao QianXianghua LiZhining LiuPublished in: Molecular medicine (Cambridge, Mass.) (2024)
This study demonstrates that KDM5C inhibits PFDN5 transcription, thereby activating c-Myc signal transduction and promoting CRC progression.