Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case-control study in the Tunisian population and a meta-analysis.
Hamza DallaliMeriem HechmiImane MorjaneSahar ElouejHaifa JmelYosra Ben HalimaAbdelmajid AbidAfef BahlousAbdelhamid BarakatHenda JamoussiSonia AbdelhakRym KefiPublished in: Diabetology & metabolic syndrome (2022)
Our findings exclude the involvement of the three HNF1A variants rs1169288, rs2464196 and rs735396 in the susceptibility to MetS in our studied Tunisian population but emphasize the role of these variants in the cholesterol homeostasis with sex-specific differences, which may serve to rise clinical consideration to early statin therapy in women carrying these genetic variants.
Keyphrases
- copy number
- metabolic syndrome
- genome wide
- polycystic ovary syndrome
- cardiovascular disease
- nuclear factor
- low density lipoprotein
- coronary artery disease
- insulin resistance
- uric acid
- type diabetes
- immune response
- pregnant women
- pregnancy outcomes
- inflammatory response
- cardiovascular risk factors
- toll like receptor
- cervical cancer screening