Proximal renal tubular function in HIV-infected children on tenofovir disoproxil fumarate for treatment of HIV infection at two tertiary hospitals in Harare, Zimbabwe.
Runyararo Mashingaidze-ManoMutsawashe F Bwakura-DangarembiziCharles C MapongaGene D MorseTsitsi G Monera-PendukaTakudzwa J MtisiTinashe MudzvitiHilda Angela MujuruPublished in: PloS one (2020)
Tubular dysfunction was uncommon in Zimbabwean children on a TDF-based ART regimen. Hypophosphatemia, proteinuria and reduction in eGFR were common. Reassessing renal function using more sensitive biomarkers is needed to examine the long-term tolerance of TDF.