lncRNA JPX-Enriched Chromatin Microenvironment Mediates Vascular Smooth Muscle Cell Senescence and Promotes Atherosclerosis.
Jiaming GuJiajing ChenQuanwen YinMengdie DongYunjia ZhangMinghong ChenXiang ChenJiao MinXian HeYongkang TanLongbin ZhengHong JiangBingjian WangXuesong LiHongshan ChenPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
As an enhancer RNA, JPX can integrate P65 and BRD4 to form a chromatin remodeling complex, activating SASP gene transcription and promoting cellular senescence. These findings suggest that JPX is a potential therapeutic target for the treatment of age-related atherosclerosis.
Keyphrases
- smooth muscle
- dna damage
- transcription factor
- genome wide
- gene expression
- cardiovascular disease
- endothelial cells
- genome wide identification
- single cell
- stem cells
- stress induced
- oxidative stress
- signaling pathway
- copy number
- cell therapy
- dna methylation
- long non coding rna
- type diabetes
- binding protein
- risk assessment
- long noncoding rna
- human health
- replacement therapy