POLE gene hotspot mutations in advanced pancreatic cancer.
Michael GuentherVivien VeningaJoerg KumbrinkMichael HaasC Benedikt WestphalenStephan KrugerVolker HeinemannThomas KirchnerStefan BoeckAndreas JungSteffen OrmannsPublished in: Journal of cancer research and clinical oncology (2018)
Mutations in the hotspot regions of exon 9 and 13 of the POLE gene are very rare events in advanced pancreatic cancer. Thus, it is unlikely that POLE gene mutations contribute to genetic instability in the vast majority of aPDAC. POLE mutation does not serve as a relevant biomarker and should not be tested on a regular basis in PDAC.