The impact of comparative genomic hybridization/single-nucleotide polymorphism microarray in risk stratification of pediatric acute lymphoblastic leukemia.

Antoine GourmelHéloïse PerraultMarie-Laure ColaiacovoLouise LaraméeMarieke RozendaalHenrique BittencourtCaroline LaverdièreJosette ChampagneSonia CellotLewis B SilvermanEmmanuelle LemyreCatalina MafteiGéraldine MathonnetFrédérique TihyMarie-Claude Pelland-MarcotteFrance LéveilléThai Hoa Tran

Published in: Pediatric blood & cancer (2024)

CGH/SNP provided faster, reliable, and highly concordant results than those obtained by conventional cytogenetics. CGH/SNP identified recurrent gene deletions in pediatric ALL, of which ETV6 deletion conferred a favorable prognosis.

Keyphrases

acute lymphoblastic leukemia
genome wide
copy number
allogeneic hematopoietic stem cell transplantation
dna methylation
high density
gene expression
young adults
childhood cancer