Tumor necrosis factor alpha (TNF-α) and its soluble receptors are associated with disability, disability progression and clinical forms of multiple sclerosis.
Claudia Mara RibeiroSayonara Rangel OliveiraDaniela Frizon AlfieriTamires FlauzinoDamacio Ramón Kaimen-MacielAndréa Name Colado SimãoMichael MaesEdna Maria Vissoci ReichePublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2019)
Increased sTNFR1 and age were positively associated with disability and disability progression, whereas increased sTNFR1 (positively) and sTNFR2 (negatively) were associated with ProgMS, suggesting a distinct role of them in the immunopathological mechanisms of MS.