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Efficient Use of Photons in Photoredox/Enamine Dual Catalysis with a Peptide-Bridged Flavin-Amine Hybrid.

Takuma TagamiYukihiro ArakawaKeiji MinagawaYasushi Imada
Published in: Organic letters (2019)
An isoalloxazine (flavin) ring system and a secondary amine have been integrated through a short peptide linker with the aim of using photons as efficiently as possible in photoredox/enamine dual catalysis. We herein report a peptide-bridged flavin-amine hybrid that can catalyze α-oxyamination of aldehydes with TEMPO under weak blue light irradiation to achieve an extremely high quantum yield of reaction (Φ = 0.80).
Keyphrases
  • visible light
  • molecular dynamics
  • radiation therapy
  • radiation induced
  • electron transfer