The abscopal effect: systematic review in patients with brain and spine metastases.

Dhiraj J PangalBenjamin YarovinskyTyler CardinalDavid J CoteJacob RuzevickFrank J AttenelloEric L ChangJason YeJosh NemanFrances ChowGabriel Zada

Published in: Neuro-oncology advances (2022)

Abscopal effects can occur following radiotherapy in patients with brain or spine metastases and is thought to be a result of increased anti-tumor immunity. The potential for immune checkpoint inhibitor therapy to be used in combination with radiotherapy to induce an abscopal effect is an area of active investigation.

Keyphrases

systematic review
early stage
white matter
resting state
locally advanced
radiation therapy
radiation induced
functional connectivity
squamous cell carcinoma
cerebral ischemia
multiple sclerosis
risk assessment
mesenchymal stem cells
rectal cancer