Rapid chemical characterization of Danggui Buxue Decoction with processed Astragali Radix and Angelicae Sinensis Radix based on diagnostic ion and molecular network.

Danggui Buxue Decoction (DBD), a classic prescription for invigorating qi and generating blood of TCM, containing honey-processed Astragali Radix (HAR) and wine-processed Angelicae Sinensis Radix (WDG) in its original prescription. In this study, the compositions of DBD, WDG and HAR were characterized using UPLC-Q-TOF-MS/MS technique in combination with molecular network (MN) and diagnostic ion strategies. Finally, 200 compounds were identified in DBD, 114 compounds were identified in WDG, and 180 compounds were identified in HAR; there were 48 common compounds in total. The results demonstrated that compatibility leaded to changes in the chemical composition of TCM, and the qualitative method in this paper provided an effective data processing strategy for the characterization of components and provides data foundation for the study of the compounding mechanism of TCM.