The angiotensin II type 1 receptor blocker azilsartan can overwhelm the sympathetic nerve activation stimulated by coadministration of calcium channel blockers.

Michio FukudaYukako Isobe-SasakiRyo SatoToshiyuki MiuraMasashi MizunoMinamo OnoKen KiyonoYoshiharu YamamotoJunichiro HayanoNobuyuki Ohte

Published in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2019)

CCBs, as well as diuretics, are recommended as second-line antihypertensive agents. Our results suggested that ARBs can overwhelm the activation of sympathetic nerve activity stimulated by coadministration of L-type CCBs.

Keyphrases

angiotensin ii
angiotensin converting enzyme
vascular smooth muscle cells
blood pressure
peripheral nerve