Impaired migratory phenotype of CD4 + T cells in Parkinson's disease.
Dejan MamulaShervin KhosousiYachao HeVesna LazarevicPer SvenningssonPublished in: NPJ Parkinson's disease (2022)
Dysfunctions in the immune system appear implicated in both disease onset and progression of Parkinson's disease (PD). Neurodegeneration observed in the brain of PD patients has been associated with neuroinflammation that is linked to alterations in peripheral adaptive immunity, where CD4 + T cells are key players. In the present study, we elucidated the immunological aspect of PD by employing a wide range of cellular assays, immunocytochemistry and flow cytometry to examine CD4 + T cells. We particularly investigated the role of CD4 + T cell migration in the proper functioning of the adaptive immune system. Our data reveal the altered migration potential of CD4 + T cells derived from PD patients, along with impaired mitochondrial positioning within the cell and reduced mitochondrial functionality. In addition, a cross-sectional study of p11 levels in CD4 + T cell subsets showed a differentially increased level of p11 in Th1, Th2 and Th17 populations. Taken together, these results demonstrate major impairments in the functionality of peripheral CD4 + T cells in PD.
Keyphrases
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- cell migration
- oxidative stress
- prognostic factors
- traumatic brain injury
- risk assessment
- stem cells
- peritoneal dialysis
- gene expression
- multiple sclerosis
- physical activity
- risk factors
- patient reported outcomes
- cell therapy
- big data
- white matter
- mass spectrometry
- climate change
- lipopolysaccharide induced
- genome wide
- mesenchymal stem cells
- brain injury
- artificial intelligence
- functional connectivity
- resting state
- single molecule