Exposure of benzo[a]pyrene induces HCC exosome-circular RNA to activate lung fibroblasts and trigger organotropic metastasis.

Wei MuPengfei GuHuating LiJinjin ZhouYulun JianWeiping JiaYang Ge

Published in: Cancer communications (London, England) (2024)

We demonstrated that B[a]P-induced tumor exosomes can deliver circ_0011496 to activate miR-486-5p/TWF1/MMP9 cascade in the lung fibroblasts, generating a feedback loop that promoted HCC metastasis.

Keyphrases

extracellular matrix
mesenchymal stem cells
high glucose
stem cells
diabetic rats
transcription factor
drug induced
oxidative stress
bone marrow