Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2.
Naasson M MbenzaNawal NasarudinPraveen G VadakkedathKamal PatelA Z IsmailMuhammad HanifL James WrightVijayalekshmi SarojiniChristian G HartingerIvanhoe K H LeungPublished in: Chembiochem : a European journal of chemical biology (2021)
Hypoxia-inducible factor prolyl hydroxylase domain 2 (PHD2) is an important oxygen sensor in animals. By using the CO-releasing molecule-2 (CORM-2) as an in situ CO donor, we demonstrate that CO is an inhibitor of PHD2. This report provides further evidence about the emerging role of CO in oxygen sensing and homeostasis.
Keyphrases