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Rheumatoid Arthritis Morning Stiffness Is Associated With Synovial Fibrin and Neutrophils.

Dana E OrangeNathalie E BlachereEdward F DiCarloSerene MirzaTania PannelliniCaroline S JiangMayu O FrankSalina ParveenMark P FiggieEllen M GravalleseVivian P BykerkAna Maria OrbaiSarah L MackieSusan M Goodman
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
In RA, prolonged morning stiffness may be related to impaired fibrinolysis of neutrophil-enmeshed fibrin deposits along the synovial membrane. Our findings also suggest that morning stiffness severity and duration may reflect distinct pathophysiologic phenomena.
Keyphrases
  • rheumatoid arthritis
  • disease activity
  • ankylosing spondylitis
  • interstitial lung disease
  • systemic lupus erythematosus
  • systemic sclerosis
  • idiopathic pulmonary fibrosis