Rheumatoid Arthritis Morning Stiffness Is Associated With Synovial Fibrin and Neutrophils.
Dana E OrangeNathalie E BlachereEdward F DiCarloSerene MirzaTania PannelliniCaroline S JiangMayu O FrankSalina ParveenMark P FiggieEllen M GravalleseVivian P BykerkAna Maria OrbaiSarah L MackieSusan M GoodmanPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
In RA, prolonged morning stiffness may be related to impaired fibrinolysis of neutrophil-enmeshed fibrin deposits along the synovial membrane. Our findings also suggest that morning stiffness severity and duration may reflect distinct pathophysiologic phenomena.