The component of the m6A writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors.
Vera Miranda-GonçalvesJoão LoboCatarina Guimarães-TeixeiraDaniela Barros-SilvaRita GuimarãesMariana CantanteIsaac BragaJoaquina MaurícioChristoph OingFriedemann HoneckerDaniel NettersheimLeendert H J LooijengaRui M HenriqueCarmen JerónimoPublished in: Journal of experimental & clinical cancer research : CR (2021)
VIRMA has an oncogenic role in GCTs confirming our previous tissue-based study and is further involved in response to cisplatin by interfering with DNA repair. These data contribute to our better understanding of the emergence of cisplatin resistance in GCTs and support recent attempts to therapeutically target elements of the m6A writer complex.