The Role of Circular RNA for Early Diagnosis and Improved Management of Patients with Cardiovascular Diseases.
Claudia Alexandrina GoinaDaniela Marcela GoinaSimona Sorina FarcasNicoleta Ioana AndreescuPublished in: International journal of molecular sciences (2024)
Cardiovascular diseases (CVDs) are responsible for approximately 17.9 million deaths every year. There is growing evidence that circular RNAs (circRNAs) may play a significant role in the early diagnosis and treatment of cardiovascular diseases. As regulatory molecules, circular RNAs regulate gene expression, interact with proteins and miRNAs, and are translated into proteins that play a key role in a wide variety of biological processes, including the division and proliferation of cells, as well as the growth and development of individuals. An overview of the properties, expression profiles, classification, and functions of circRNAs is presented here, along with an explanation of their implications in cardiovascular diseases including heart failure, hypertension, ischemia/reperfusion injury, myocardial infarction, cardiomyopathies, atherosclerosis, and arrhythmia.
Keyphrases
- cardiovascular disease
- heart failure
- gene expression
- ischemia reperfusion injury
- cardiovascular risk factors
- blood pressure
- induced apoptosis
- left ventricular
- type diabetes
- cardiovascular events
- oxidative stress
- deep learning
- signaling pathway
- cell cycle arrest
- cell proliferation
- metabolic syndrome
- acute heart failure