Pharmacologic inhibition of eIF4A blocks NRF2 synthesis to prevent osteosarcoma metastasis.
Michael M LizardoChristopher S HughesYue Zhou HuangTaras ShypAlberto DelaidelliHai-Feng ZhangSol Snir ShaoolAnnalena F RennerFares BurwagLeanne C SaylesAlex G LeeE Alejandro Sweet-CorderoPoul H SorensenPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Collectively, our data reveal that pharmacologic targeting of eIF4A1 is highly effective in blocking OS metastasis by blunting the NRF2 antioxidant response.