Pharmacologic inhibition of eIF4A blocks NRF2 synthesis to prevent osteosarcoma metastasis.

Michael M Lizardo Christopher S Hughes Yue Zhou Huang Taras Shyp Alberto Delaidelli Hai-Feng Zhang Sol Snir Shaool Annalena F Renner Fares Burwag Leanne C Sayles Alex G Lee E Alejandro Sweet-Cordero Poul H Sorensen

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Collectively, our data reveal that pharmacologic targeting of eIF4A1 is highly effective in blocking OS metastasis by blunting the NRF2 antioxidant response.

Keyphrases

oxidative stress
single cell
cancer therapy
anti inflammatory
gene expression