Systemic microvascular endothelial dysfunction is associated with left ventricular ejection fraction reduction in chronic Chagas disease patients.
Daniel Arthur Barata KasalAdemar BrittoValéria VerriAndrea De LorenzoEduardo TibiriçáPublished in: Microcirculation (New York, N.Y. : 1994) (2020)
We have shown for the first time that the reduction of MR is associated with a decrease of LVEF in a cohort of chronic CD patients. The results were not affected by comorbidities, such as hypertension or diabetes. The evaluation of systemic endothelial function may be useful to tailor therapeutic and preventive approaches, targeted at systolic left ventricular failure associated with chronic CD cardiomyopathy.
Keyphrases
- ejection fraction
- aortic stenosis
- left ventricular
- end stage renal disease
- heart failure
- chronic kidney disease
- blood pressure
- type diabetes
- magnetic resonance imaging
- adipose tissue
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- atrial fibrillation
- mitral valve
- drug delivery
- aortic valve
- patient reported outcomes
- cancer therapy
- drug induced