Imaging HDACs In Vivo: Cross-Validation of the [11C]Martinostat Radioligand in the Pig Brain.

L L DonovanJ H MagnussenA DyssegaardS LehelJ M HookerG M KnudsenHanne Demant Hansen

Published in: Molecular imaging and biology (2021)

We found good correlation between in vivo measured SUV ratios and in vitro measures of HDAC 1-3 proteins, supporting that [11C]Martinostat provides a good in vivo measure of the cerebral HDAC1-3 protein levels.

Keyphrases

histone deacetylase
cerebral ischemia
high resolution
subarachnoid hemorrhage
white matter
resting state
protein protein
brain injury
blood brain barrier
fluorescence imaging