Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance.

Ramesh PothurajuSatyanarayana RachaganiShiv Ram KrishnSanjib ChaudharyRama Krishna NimmakayalaJawed A SiddiquiKoelina GangulyImayavaramban LakshmananJesse L CoxKavita MallyaSukhwinder KaurSurinder Kumar Batra

Published in: Molecular cancer (2020)

Our findings suggest that differential expression of secretory mucin MUC5AC results in enhanced tumorigenesis and also confers chemoresistance via CD44/β-catenin/p53/p21 signaling.

Keyphrases

nk cells
cell proliferation
epithelial mesenchymal transition
cancer stem cells
signaling pathway