Visual Multifunctional Aggregation-Induced Emission-Based Bacterial Cellulose for Killing of Multidrug-Resistant Bacteria.

Multidrug resistant (MDR) bacteria-related wound infections have long been thorny issues. It is urgent to develop new antibacterial wound dressings that can not only prevent wounds from MDR bacteria infection but also promote wound healing. Herein, we present an aggregation-induced emission (AIE) molecule BITT-composited bacterial cellulose (BC) as wound dressings. BC-BITT composites had good transparency, making it easy to monitor the wound healing process through the composite membrane. The BC-BITT composites retained the advantages of biocompatible BC, and displayed photodynamic and photothermal synergistic antibacterial effects under irradiation of a 660 nm laser. Furthermore, the BC-BITT composites showed excellent wound healing performance in a mouse full-thickness skin wound model infected by MDR bacteria, simultaneously with negligible toxicity. Our study paves a way for treating clinically troublesome wound infections. This article is protected by copyright. All rights reserved.