DPP-4 inhibitors promote proliferation and migration of rat brain microvascular endothelial cells under hypoxic/high-glucose conditions, potentially through the SIRT1/HIF-1/VEGF pathway.
Dong-Hua MiHong-Juan FangGuang-Hui ZhengXian-Hong LiangYa-Rong DingXin LiuLi-Ping LiuPublished in: CNS neuroscience & therapeutics (2018)
The protection of rBMVECs from hypoxia/high-glucose induced impairment by DPP-4 inhibitors may be mediated by the SIRT1/HIF-1α/VEGF pathway.