Mycobacterial Immune Reconstitution Inflammatory Syndrome in HIV is Associated With Protein-Altering Variants in Hemophagocytic Lymphohistiocytosis-Related Genes.
Joseph M RoccoElizabeth LaidlawFrances GalindoMegan AndersonOrnella SortinoSafia KuriakoseAndrea LiscoMaura ManionIrini SeretiPublished in: The Journal of infectious diseases (2023)
People with HIV (PWH) and mycobacterial infections can develop immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy. The pathophysiology of mycobacterial-IRIS overlaps with primary hemophagocytic lymphohistiocytosis (pHLH). To assess possible genetic predisposition to IRIS, protein-altering variants in genes associated with HLH were evaluated in 82 PWH and mycobacterial infections who developed IRIS (n = 56) or did not develop IRIS (n = 26). Protein-altering variants in cytotoxicity genes were found in 23.2% of IRIS patients compared to only 3.8% of those without IRIS. These findings suggest a possible genetic component in the risk of mycobacterial IRIS in PWH. Clinical Trials Registration. NCT00286767, NCT02147405.
Keyphrases
- antiretroviral therapy
- mycobacterium tuberculosis
- hiv infected
- copy number
- hiv positive
- human immunodeficiency virus
- clinical trial
- genome wide
- end stage renal disease
- oxidative stress
- hepatitis c virus
- hiv testing
- chronic kidney disease
- amino acid
- newly diagnosed
- hiv infected patients
- men who have sex with men
- ejection fraction
- case report
- prognostic factors
- gene expression
- open label
- dna methylation
- transcription factor
- peritoneal dialysis
- genome wide analysis