Dysregulation and epigenetic reprogramming of NRF2 signaling axis promote acquisition of cisplatin resistance and metastasis in Head and Neck Squamous Cell Carcinoma.
Abdullah A OsmanEmre ArslanMason BartelsChieko MichikawaAntje LindemannKatarzyna TomczakWangjie YuVlad C SandulacheWencai MaLi ShenJing WangAnand Kamal SinghMitchell J FrederickNakia D SpencerJeffrey J KovacsTimothy P HeffernanWilliam Fraser SymmansKunal RaiJeffrey N MyersPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
CDDP resistance and development of distant metastasis are associated with dysregulated and epigenetically reprogrammed KEAP1-NRF2 signaling pathway. A strategy targeting KEAP1/NRF2 pathway or glutamine metabolism deserves further clinical investigation in patients with CDDP resistant head and neck tumors.