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Associations of Vascular Risk and Amyloid Burden with Subsequent Dementia.

Rebecca F GottesmanAozhou WuJosef CoreshDavid S KnopmanClifford R JackArman RahmimA Richey SharrettAdam P SpiraDean F WongLynne E WagenknechtTimothy M HughesKeenan A WalkerThomas H Mosley
Published in: Annals of neurology (2022)
Midlife hypertension and late life Aβ are independently associated with dementia risk, without evidence for synergy on a multiplicative scale. Given the independent contributions of vascular and amyloid mechanisms, multiple pathways should be considered when evaluating interventions to reduce the burden of dementia. ANN NEUROL 2022;92:607-619.
Keyphrases
  • mild cognitive impairment
  • cognitive impairment
  • blood pressure
  • physical activity