Associations of Vascular Risk and Amyloid Burden with Subsequent Dementia.
Rebecca F GottesmanAozhou WuJosef CoreshDavid S KnopmanClifford R JackArman RahmimA Richey SharrettAdam P SpiraDean F WongLynne E WagenknechtTimothy M HughesKeenan A WalkerThomas H MosleyPublished in: Annals of neurology (2022)
Midlife hypertension and late life Aβ are independently associated with dementia risk, without evidence for synergy on a multiplicative scale. Given the independent contributions of vascular and amyloid mechanisms, multiple pathways should be considered when evaluating interventions to reduce the burden of dementia. ANN NEUROL 2022;92:607-619.