The Protective Effect of Anethole against Renal Ischemia/Reperfusion: The Role of the TLR2,4/MYD88/NFκB Pathway.

Maged Elsayed Mohamed Mahmoud Kandeel Hany M Abd El-Lateef Hossam S El-Beltagi Nancy S Younis

Published in: Antioxidants (Basel, Switzerland) (2022)

Anethole displayed anti-inflammatory, anti-oxidant, and anti-apoptotic actions against RIR-induced injury. Anethole exhibited renal protective actions, which could be through inhibiting the HMGB1/TLR2, 4/MYD88/NFκB pathway. These results could suggest anethole as a protective agent against RIR.

Keyphrases

toll like receptor
anti inflammatory
nuclear factor
signaling pathway
inflammatory response
lps induced
immune response
pi k akt
oxidative stress
cell death
high glucose
diabetic rats
drug induced
cell proliferation
endothelial cells