Targeting the Microbiome to Improve Gut Health and Breathing Function After Spinal Cord Injury.
Jessica N WilsonKristina A KigerlMichael D SunshineChase E TaylorSydney L SpeedBreanna C RoseChris M CalulotBrittany E DongTara R HawkinsonHarrison A ClarkeAdam D BachstetterChristopher M WatersRamon C SunPhillip G PopovichWarren J AlilainPublished in: bioRxiv : the preprint server for biology (2023)
Cervical spinal cord injury (SCI) causes transient gut dysbiosis and persistent gastrointestinal (GI) pathology.Treatment with probiotics after SCI leads to a healthier GI tract and improved respiratory motor recovery.Probiotic treatment decreases systemic tumor necrosis factor-alpha and increases the potential for sprouting and regeneration of neurons after SCI.The gut microbiome is a valid target to improve motor function and secondary visceral health after SCI.