Taohuajing reduces oxidative stress and inflammation in diabetic cardiomyopathy through the sirtuin 1/nucleotide-binding oligomerization domain-like receptor protein 3 pathway.
Rui YaoYu CaoChangming WangLu XuXuan ZhangYuqing DengFeng LiSi-Wang WangPublished in: BMC complementary medicine and therapies (2021)
Overall, THJ protected the heart from hyperglycemia-induced oxidative stress and inflammation in DCM mice via a mechanism involving SIRT1-mediated antioxidant proteins and suppression of the NLRP3 inflammasome.
Keyphrases
- oxidative stress
- nlrp inflammasome
- diabetic rats
- ischemia reperfusion injury
- dna damage
- heart failure
- induced apoptosis
- binding protein
- type diabetes
- hydrogen peroxide
- atrial fibrillation
- high fat diet induced
- protein protein
- skeletal muscle
- adipose tissue
- nitric oxide
- dna binding
- endoplasmic reticulum stress
- heat stress