Zinc Oxide Quantum Dots May Provide a Novel Potential Treatment for Antibiotic-Resistant Streptococcus agalactiae in Lama glama .
Ziyao ZhouTing ZhangYixin ChenXiaoxiao ZhouYalin ZhongHai-Feng LiuZhijun ZhongYanchun HuFei LiaoXianxiang WangGuangneng PengPublished in: Molecules (Basel, Switzerland) (2023)
Streptococcus agalactiae is a significant pathogen that can affect both human beings and animals. The extensive current use of antibiotics has resulted in antibiotic resistance. In our previous research, we found that zinc oxide quantum dots (ZnO QDs) had inhibitory effects on antibiotic-resistant microorganisms. In this study, a strain of Streptococcus agalactiae WJYT1 with a broad antibiotic-resistant spectrum was isolated and identified from Lama glama at Sichuan Agricultural University Teaching Animal Hospital. The genome for the resistance and virulence genes was analyzed. Additionally, the antibacterial effects and anti-virulence mechanism of ZnO QDs for S. agalactiae WJYT1 were investigated. The results showed that the genome of S. agalactiae WJYT1 is 1,943,955 bp, containing 22 resistance genes and 95 virulence genes. ZnO QDs have a good antibacterial effect against S. agalactiae WJYT1 by reducing bacterial growth and decreasing the expression of virulence genes, including bibA , hylB , sip , and cip , which provides a novel potential treatment for S. agalactiae .
Keyphrases
- quantum dots
- biofilm formation
- pseudomonas aeruginosa
- genome wide
- escherichia coli
- staphylococcus aureus
- candida albicans
- antimicrobial resistance
- bioinformatics analysis
- room temperature
- genome wide identification
- sensitive detection
- healthcare
- dna methylation
- risk assessment
- human health
- emergency department
- heavy metals
- cystic fibrosis
- climate change
- oxide nanoparticles
- silver nanoparticles
- transcription factor
- anti inflammatory
- long non coding rna