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A uro-protective agent with restorative actions on urethral and striated muscle morphology.

Lori Ann BirderAmanda Wolf-JohnstonAlan J WeinMara Grove-SullivanDonna StoltzSimon WatkinsDiane NewmanRoger R DmochowskiEdwin K Jackson
Published in: World journal of urology (2020)
8-AG, a potent inhibitor of PNPase, reverses age-related lower urinary tract morphological and biochemical changes. Our observations support the concept that 8-AG will reverse age-induced lower urinary tract disorders such as UI. These initial findings could have therapeutic implications for the prevention and treatment of age-related UI.
Keyphrases
  • urinary tract
  • quantum dots
  • high glucose
  • skeletal muscle
  • diabetic rats
  • drug induced
  • endothelial cells
  • oxidative stress
  • combination therapy
  • anti inflammatory