A uro-protective agent with restorative actions on urethral and striated muscle morphology.
Lori Ann BirderAmanda Wolf-JohnstonAlan J WeinMara Grove-SullivanDonna StoltzSimon WatkinsDiane NewmanRoger R DmochowskiEdwin K JacksonPublished in: World journal of urology (2020)
8-AG, a potent inhibitor of PNPase, reverses age-related lower urinary tract morphological and biochemical changes. Our observations support the concept that 8-AG will reverse age-induced lower urinary tract disorders such as UI. These initial findings could have therapeutic implications for the prevention and treatment of age-related UI.