In vitro activity of human defensins HNP-1 and hBD-3 against multidrug-resistant ESKAPE Gram-negatives of clinical origin and selected peptidoglycan recycling-defective mutants.
María Escobar-SalomIsabel María BarcelóEstrella Rojo-MolineroElena Jordana-LluchGabriel CabotAntonio OliverCarlos JuanPublished in: Microbiology spectrum (2024)
strains from chronic infection compared to acute origin ones, and provide new clues about the predominant mode of action of hBD-3 against Gram-negatives (permeabilization rather than peptidoglycan-targeting).
Keyphrases
- gram negative
- multidrug resistant
- drug resistant
- acinetobacter baumannii
- endothelial cells
- cell wall
- liver failure
- drug induced
- klebsiella pneumoniae
- escherichia coli
- bacillus subtilis
- respiratory failure
- induced pluripotent stem cells
- cancer therapy
- pseudomonas aeruginosa
- drug delivery
- hepatitis b virus
- cystic fibrosis