Cannabinoid-1 receptor regulates mitochondrial dynamics and function in renal proximal tubular cells.

Adi DroriAnna PermyakovaRivka HadarShiran UdiAlina NemirovskiJoseph Tam

Published in: Diabetes, obesity & metabolism (2018)

CB1 R plays a key role in inducing mitochondrial fragmentation in RPTCs, leading to a decline in the organelle's function and contributing to the renal tubular injury associated with lipotoxicity and other metabolic diseases.

Keyphrases

oxidative stress
induced apoptosis
cell cycle arrest
high glucose
endothelial cells
cell proliferation