Inhibitor of apoptosis proteins are potential targets for treatment of granulosa cell tumors - implications from studies in KGN.

Konstantin BagnjukVerena Jasmin KastAstrid TiefenbacherMelanie KasederToshihiko YanaseAlexander BurgesLars KunzDoris MayrMayerhofer Artur

Published in: Journal of ovarian research (2019)

Taken together, the results show that BV-6 is able to induce apoptosis in KGN cells. This approach may therefore offer a promising therapeutic avenue to treat GCTs.

Keyphrases

cell cycle arrest
cell death
endoplasmic reticulum stress
induced apoptosis
pi k akt
oxidative stress
single cell
lipopolysaccharide induced
stem cells
polycystic ovary syndrome
lps induced
adipose tissue
insulin resistance
mesenchymal stem cells
skeletal muscle
case control
smoking cessation