Long-term live imaging and multiscale analysis identify heterogeneity and core principles of epithelial organoid morphogenesis.

Lotta HofTill MorethMichael KochTim LiebischMarina KurtzJulia TarnickSusanna M LissekMonique M A VerstegenLuc J W van der LaanMeritxell HuchFranziska MatthäusErnst H K StelzerFrancesco Pampaloni

Published in: BMC biology (2021)

Our multiscale analysis provides a systematic picture of the diversity of cell organisation in organoids by identifying and quantifying the core regulatory principles of organoid morphogenesis.

Keyphrases

single cell
high resolution
transcription factor
cell therapy
bone marrow
mass spectrometry