Reverse vaccinology and subtractive genomics approaches for identifying common therapeutics against Mycobacterium leprae and Mycobacterium lepromatosis.

Arun Kumar Jaiswal Sandeep Tiwari Syed Babar Jamal Letícia de Castro Oliveira Helioswilton Sales-Campos Leonardo Eurípedes de Andrade Silva Carlo José Freire de Oliveira Preetam Ghosh Debmalya Barh Vasco Ariston de Carvalho Azevedo Siomar de Castro Soares Virmondes Rodrigues Júnior Marcos Vinícius da Silva

Published in: The journal of venomous animals and toxins including tropical diseases (2021)

The bis-naphthoquinone compound Diospyrin (CID 308140) obtained from indigenous plant Diospyros spp. showed the most favored binding affinity against predicted drug targets, which can be a candidate therapeutic target in the future against leprosy.

Keyphrases

mycobacterium tuberculosis
current status
small molecule
single cell
ionic liquid
emergency department
dna binding
binding protein
adverse drug
drug induced
cell wall