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Kupffer cell diversity maintains liver function in alcohol-associated liver disease.

Kyo SasakiSheetalnath RoogeSumedha GunewardenaJanice Averilla HintzPriyanka GhoshIsabel Aranzazu Pulido RuizKyle YuquimpoMichael SchonfeldHeer MetaHeather L StevensonOmar A SaldarriagaEsteban ArroyaveIrina TikhanovichAnn L WozniakSteven A Weinman
Published in: Hepatology (Baltimore, Md.) (2024)
In this ALD model, KCs are anti-inflammatory and are critical for maintenance of hepatocyte differentiation. IMs are largely pro-inflammatory and contribute more to liver fibrosis. Future targeting of specific macrophage subsets may provide new approaches to treatment of liver failure and fibrosis in ALD.
Keyphrases
  • liver fibrosis
  • liver failure
  • anti inflammatory
  • hepatitis b virus
  • single cell
  • adipose tissue
  • peripheral blood
  • current status
  • cancer therapy
  • stem cells
  • alcohol consumption
  • drug delivery
  • smoking cessation