Kupffer cell diversity maintains liver function in alcohol-associated liver disease.
Kyo SasakiSheetalnath RoogeSumedha GunewardenaJanice Averilla HintzPriyanka GhoshIsabel Aranzazu Pulido RuizKyle YuquimpoMichael SchonfeldHeer MetaHeather L StevensonOmar A SaldarriagaEsteban ArroyaveIrina TikhanovichAnn L WozniakSteven A WeinmanPublished in: Hepatology (Baltimore, Md.) (2024)
In this ALD model, KCs are anti-inflammatory and are critical for maintenance of hepatocyte differentiation. IMs are largely pro-inflammatory and contribute more to liver fibrosis. Future targeting of specific macrophage subsets may provide new approaches to treatment of liver failure and fibrosis in ALD.