Improved Cardiac Performance and Decreased Arrhythmia in Hypertrophic Cardiomyopathy With Non-β-Blocking R-Enantiomer Carvedilol.
Kinya SeoYuta YamamotoAnna KirillovaMasataka KawanaSunil YadavYong HuangQianru WangKerry V LaneBeth L PruittMarco Valentin PerezDaniel BernsteinJoseph C WuMatthew T WheelerVictoria N ParikhEuan A AshleyPublished in: Circulation (2023)
-adrenergic receptor and RyR2 in mouse and human models of HCM. This combination of therapeutic effects is unique among current therapeutic options for HCM and may particularly benefit patients without LV outflow tract obstruction.