Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts.

Tine De CosterHeleen MassetOlga TšuikoMaaike CatteeuwYan ZhaoNicolas DierckxsensAinhoa Larreategui AparicioEftychia DimitriadouSophie DebrockKaren PeeraerMarta de Ruijter-VillaniKatrien SmitsAnn Van SoomJoris Robert Vermeesch

Published in: Genome biology (2022)

Heterogoneic zygotic division provides an overarching paradigm for the development of mixoploid and chimeric individuals and moles and can be an important cause of embryonic and fetal arrest following natural conception or IVF.

Keyphrases

cell therapy
cell cycle
mesenchymal stem cells
pregnancy outcomes
pregnant women
bone marrow