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An advanced case of gastric histiocytic sarcoma treated with chemotherapy and gastrectomy: a case report and review of literature.

Ryu MatsunagaYoshikazu KanazawaKunihiko MatsunoDaisuke KakinumaTaichiro TokuraAtsushi MarumoShunsuke YuiFumihiko AndoYuka MasudaNobutoshi HagiwaraTsutomu NomuraShunji KatoToshiro YoshiyukiYukako DomotoTakashi SakataniRyuji OhashiKoiti InokuchiHiroshi Yoshida
Published in: Clinical journal of gastroenterology (2021)
Histiocytic sarcoma is a relatively new disease category and the gastrointestinal origin is sporadic. We report a case of a 74-year-old woman who underwent chemotherapy and proximal gastrectomy for extremely rare, advanced gastric histiocytic sarcoma. The resected specimen was subjected to numerous immunostainings to meet the diagnostic criteria of histiocytic sarcoma and was positive for the histiocyte markers' cluster of differentiation 68 and lysozyme. The markers of Langerhans cells, follicular dendritic cells, and myelocyte were all negative. Six reports of surgical resection of histiocytic sarcoma originating in the stomach exist, including our case. We reviewed the clinical course and the histological and immunohistochemical diagnostic features of surgically resected gastric histiocytic sarcoma.
Keyphrases
  • dendritic cells
  • induced apoptosis
  • emergency department
  • squamous cell carcinoma
  • oxidative stress
  • signaling pathway
  • prognostic factors
  • cell death
  • newly diagnosed
  • rectal cancer
  • pi k akt