Statins and cognitive decline in the Cardiovascular Health Study: A comparison of different analytical approaches.
Adina Zeki Al HazzouriNeal JawadekarLeslie GrassetPaulina KaiserKatrina KeziosSebastian CalonicoM Maria GlymourCalvin HirschAlice M ArnoldRavi VaradhanMichelle C OpooddenPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2021)
The association of statin use and cognitive decline is attenuated towards the null when using rigorous analytical approaches that more closely mimic RCTs. Point estimates, even within the same study, may vary depending on the analytical methods used. Further studies that leverage natural or quasi experiments around statin use are needed to replicate our findings.