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Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c.

Changhan Lee
Published in: Molecular & cellular oncology (2019)
Cellular stress response is coordinated through the communication between mitochondria and the nucleus. However, whereas mitochondria are regulated by nuclear-encoded proteins, the nucleus was considered ungoverned by mitochondrial-encoded factors. We recently reported that a mitochondrial-encoded peptide directly regulates the nuclear genome upon cellular stress, indicating an integrated bi-genomic cross-communication mechanism.
Keyphrases
  • oxidative stress
  • cell death
  • reactive oxygen species
  • endoplasmic reticulum
  • genome wide
  • dna methylation
  • gene expression