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The senescence-associated secretory phenotype as a driver of tumor growth: does G3BP1 hold the key?

Amr OmerSergio Di MarcoImed Eddine Gallouzi
Published in: Molecular & cellular oncology (2021)
Cellular senescence is a double-edged sword that, depending on the context, acts as either a potent tumor protective mechanism or an age-related driver of diseases such as cancer. Our recent findings show that the rasGAP SH3-binding protein 1 (G3BP1) activates the senescent-associated secretory phenotype (SASP) that, in turn, mediates cancer growth/progression.
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