Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease.
Emilie L CastranioMichael R O'DeaJean-Vianney Haure-MirandeAngie V Ramirez JimenezB Wade HamiltonRachel D KimCharles G GlabeMinghui WangBin ZhangSamuel E GandyShane A LiddelowMichelle E EhrlichPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)
Inpp5d knockdown increases plaque burden and plaque-associated microglia number. Spatial transcriptomics identifies an expanded plaque-specific gene expression profile. Plaque-induced gene expression is altered by Inpp5d knockdown in microglia. Our plaque-associated gene signature overlaps with human Alzheimer's disease gene networks.