Circulating cardiac MicroRNAs safeguard against dilated cardiomyopathy.

Xiaolei ChengDongdong JianJunyue XingCihang LiuYong LiuCunying CuiZhen LiShixing WangRan LiXiaohan MaYingying WangXiaoping GuZhenwei GeHao TangLin Liu

Published in: Clinical and translational medicine (2023)

Circulating cardiac miRNA-FOXO3 axis plays a pivotal role in safeguarding against myocardial apoptosis and excessive autophagy in DCM development, which may provide serological cues for DCM non-invasive diagnosis and shed light on DCM pathogenesis and therapeutic targets.

Keyphrases

left ventricular
endoplasmic reticulum stress
cell death
oxidative stress
signaling pathway
transcription factor
cell cycle arrest
heart failure
pi k akt
body mass index
cell proliferation