Transcriptomic and proteomic studies suggest the establishment of advanced zonation-like profiles in hiPSCs-derived LSECs and CPM-positive LPCs cocultured in a fluidic microenvironment.
Mathieu DanoyStephane PoulainRachid JellaliBenedikt ScheideckerYannick TauranLeduc MarjorieBruce JohannaSoo Hyeon KimTaketomo KidoAtsushi MiyajimaYasuyuki SakaiEric LeclercPublished in: Hepatology research : the official journal of the Japan Society of Hepatology (2023)
The present study shows the interest in combining coculture of hiPSCs-derived cellular models and microfluidic technologies for reproducing in vitro complex mechanisms such as liver zonation and further incites the use of those solutions for accurate reproduction of in vivo situations. This article is protected by copyright. All rights reserved.