Peripheral Blood B-Cell Subsets Frequency and Distribution and the BSF-2(IL-6) to CSIF:TGIF(IL-10) Ratio as Severity-Associated Signatures in Primary Open-Angle Glaucoma: A Case-Controlled Study.
Entsar R MokhtarAsmaa A ElmadboulyOmaima I Abo ElkheirMona Nabeh MansourShahinaz El AttarMohamed A HeibaMennatullah N MohamedHeba ElhakeemLamia A GadHeba Mahmoud AbdelrahmanRehab Moustafa KamelHekmat M El MagdoubNadia M HamdyDoaa Aly Abd El-FattahPublished in: Biomedicines (2024)
The severity of the POAG disease course is accompanied by changes in the B-cell subpopulation, namely, DN B cells. Furthermore, the existing relationship of the B-cell subset frequencies with the clinical and the inflammatory parameters BSF-2(IL-6), CSIF:TGIF(IL-10), and the BSF-2(IL-6) to CSIF:TGIF(IL-10) ratio suggests that these B lymphocyte cells could serve as potential molecular bio-markers for assessing POAG disease severity and/or progression.